The Beefalo breed can have up to 3/8 Bison genetics. The other 5/8 of the genetic makeup can come from virtually any of the domestic breeds of cattle (Angus, Limousin, Hereford, etc.) or from any of the newer composite breeds (Beefmaster, Santa Gertrudis, etc.). The breeding can be accomplished by natural service, by artificial insemination, or by using newer reproductive techniques like embryo transfer. Beefalos and not sterile. If two beefalos mate, the calf will be a beefalo.